UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy

Sabin, CA; Smith, CJ; Delpech, V; Anderson, J; Bansi, L; Gilson, R; Schwenk, A; ... UK Collaborative HIV Cohort CHIC S, ; + view all (2009) The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy. HIV MED , 10 (1) 35 - 43. 10.1111/j.1468-1293.2008.00654.x.

Full text not available from this repository.

Abstract

Objective The aim of this study was to describe the relationship between age and the time to treatment discontinuation in the absence of virological failure as well as the development of specific laboratory abnormalities, in patients starting highly active antiretroviral therapy (HAART) for the first time.Methods Analyses included 8708 antiretroviral-naive patients from the UK Collaborative HIV Cohort (CHIC) study who started HAART from 1998 onwards. We considered time to the first discontinuation of any drug in the initial HAART regimen for reasons other than virological failure; the association between this and age at the start of HAART was determined using proportional hazards regression after adjustment for potential confounders. The incidence of specific laboratory abnormalities in the first year after starting HAART was compared in those of different ages using multiple logistic regression.Results A total of 2650 patients discontinued at least one drug in their HAART regimen in the first year for reasons other than virological failure; after controlling for confounders, those aged < 30 years at the time of starting HAART were more likely to discontinue than those aged 30-39 years [relative hazard (RH) 1.12; 95% confidence interval (CI) 1.01, 1.24] as were those aged X 50 years (RH 1.14; 95% CI 1.00, 1.31). There were strong associations between greater age and raised total cholesterol, decreased haemoglobin and raised triglycerides over the first year, although the latter disappeared after adjustment for pre-HAART levels, suggesting that this finding reflected higher pre-HAART triglyceride levels in older individuals.Conclusions Continued attempts to improve the tolerability of HAART regimens may help to sustain the good outcomes in all age groups over the longer term.

Type: Article
Title: The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy
DOI: 10.1111/j.1468-1293.2008.00654.x
Keywords: adverse event, age, HAART, laboratory abnormalities, risk factors, treatment discontinuation, SWISS HIV COHORT, INITIAL HAART REGIMEN, INFECTED PATIENTS, NAIVE PATIENTS, ADVERSE EVENTS, DETERMINANTS, PREVALENCE, TOXICITY, ADULTS, ERA
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/138481
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item