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Cardiovascular disease risk factors and antiretroviral therapy in an HIV-positive UK population

Smith, CJ; Levy, I; Sabin, CA; Kaya, E; Johnson, MA; Lipman, MCI; (2004) Cardiovascular disease risk factors and antiretroviral therapy in an HIV-positive UK population. HIV MED , 5 (2) 88 - 92.

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Abstract

Aim Although the benefits of antiretroviral therapy (ART) have been dramatic, studies have started to report a variety of drug-related side effects and toxicities. We sought to characterize the risk factors for cardiovascular disease present in an HIV-positive population.Methods A total of 394 HIV-positive ambulant patients attending the Royal Free Hospital, London, were asked to complete a questionnaire. Questions focused on smoking habits and general health.Results In total, 34% of patients were aged > 40 years, 29% had a family history of heart disease, 3% had diabetes, 14% suffered from raised blood pressure, 20% had a body mass index (BMI) > 26 kg/m(3), 7% had an alcohol consumption above the recommended UK limit, and 18% had total cholesterol levels > 6.3 mmol/L. The rate of smoking observed (45%) was much higher than that observed amongst the general population in the British Health Survey for England (34%). There were significant differences between those receiving and not receiving ART. Those on ART tended to be younger (P < 0.0001) and less likely to smoke cigarettes (P = 0.06) or have an alcohol consumption above the recommended limit (P = 0.08), but were more likely to have diabetes (P = 0.05). More patients receiving ART reported, and so perceived themselves to have, raised blood fats (P < 0.0001). This was confirmed when considering blood lipid levels, where those on ART had significantly raised total cholesterol levels compared to those not currently receiving ART (P < 0.0001).Conclusion We have demonstrated an excess of cardiovascular risk factors in this cohort. These issues must be addressed if we wish to maintain the benefit of treating HIV infection.

Type: Article
Title: Cardiovascular disease risk factors and antiretroviral therapy in an HIV-positive UK population
Keywords: antiretroviral therapy, cardiovascular disease, HIV, HUMAN-IMMUNODEFICIENCY-VIRUS, HEPATITIS-C VIRUS, PROTEASE INHIBITORS, INFECTION, MORTALITY, IMPACT, HAART
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/138472
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