Ridgway, G.R. and Whitcher, B. and Nichols, T. and Ourselin, S. and Hill, D. and Fox, N. (2008) Longitudinal multivariate tensor- and searchlight-based morphometry using permutation testing. Presented at: 14th Annual Meeting of the Organization for Human Brain Mapping, Melbourne, Australia.
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Abstract
Tensor based morphometry [1] was used to detect statistically significant regions of neuroanatomical change over time in a comparison between 36 probable Alzheimer's Disease patients and 20 age- and sexmatched controls. Baseline and twelve-month repeat Magnetic Resonance images underwent tied spatial normalisation [10] and longitudinal high-dimensional warps were then estimated. Analyses involved univariate and multivariate data derived from the longitudinal deformation fields. The most prominent findings were expansion of the fluid spaces, and contraction of the hippocampus and temporal region. Multivariate measures were notably more powerful, and have the potential to identify patterns of morphometric difference that would be overlooked by conventional mass-univariate analysis.
| Type: | Poster |
|---|---|
| Title: | Longitudinal multivariate tensor- and searchlight-based morphometry using permutation testing |
| Event: | 14th Annual Meeting of the Organization for Human Brain Mapping |
| Location: | Melbourne, Australia |
| Dates: | June 15 - 19, 2008 |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | http://www.humanbrainmapping.org/i4a/pages/index.cfm?pageid=3299 |
| Language: | English |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Metabolism and Experimental Therapeutics UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases |
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