Camara, O. and Scahill, R.I. and Crum, W.R. and Schnabel, J.A. and Ridgway, G.R. and Hill, D.L.G. and Fox, N.C. (2007) Evaluation of local and global atrophy measurement techniques with simulated Alzheimer's disease data. In: Proceedings of Medical Image Understanding and Analysis 2007. (pp. pp. 16-20). British Machine Vision Association: Malvern, UK.
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Abstract
The main goal of this work was to evaluate several well-known methods which provide global (BSI and SIENA) or local (Jacobian integration) estimates of atrophy in brain structures using Magnetic Resonance images. For that purpose, we have generated realistic simulated Alzheimer's disease images in which volume changes are modelled with a Finite Element thermoelastic model, which mimic the patterns of change obtained from a cohort of 19 real controls and 27 probable Alzheimer's disease patients. SIENA and BSI results correlate very well with gold standard data (BSI mean absolute error <0.29%; SIENA <0.44%). Jacobian integration was guided by both fluid and FFD-based registration techniques and resulting deformation fields and associated Jacobians were compared, region by region, with gold standard ones. The FFD registration technique provided more satisfactory results than the fluid one. Mean absolute error differences between volume changes given by the FFD-based technique and the gold standard were: sulcal CSF <2.49%; lateral ventricles 2.25%; brain <0.36%; hippocampi <0.42%.
| Type: | Proceedings paper |
|---|---|
| Title: | Evaluation of local and global atrophy measurement techniques with simulated Alzheimer's disease data |
| ISBN-13: | 9781901725339 |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | http://www2.wiau.man.ac.uk/caws/Conferences/43/ |
| Language: | English |
| Additional information: | Paper presented at the Medical Image Understanding and Analysis conference 2007, University of Wales, Aberystwyth, 17-18th July 2007 |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Metabolism and Experimental Therapeutics UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases |
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