Tiss, A;
Smith, C;
Menon, U;
Jacobs, I;
Timms, JF;
Cramer, R;
(2010)
A well-characterised peak identification list of MALDI MS profile peaks for human blood serum.
Proteomics
, 10
(18)
3388 - 3392.
10.1002/pmic.201000100.
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Abstract
MALDI MS profiling, using easily available body fluids such as blood serum, has attracted considerable interest for its potential in clinical applications. Despite the numerous reports on MALDI MS profiling of human serum, there is only scarce information on the identity of the species making up these profiles, particularly in the mass range of larger peptides. Here, we provide a list of more than 90 entries of MALDI MS profile peak identities up to 10 kDa obtained from human blood serum. Various modifications such as phosphorylation were detected among the peptide identifications. The overlap with the few other MALDI MS peak lists published so far was found to be limited and hence our list significantly extends the number of identified peaks commonly found in MALDI MS profiling of human blood serum.
| Type: | Article |
|---|---|
| Title: | A well-characterised peak identification list of MALDI MS profile peaks for human blood serum |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/pmic.201000100 |
| Publisher version: | http://dx.doi.org/10.1002/pmic.201000100 |
| Language: | English |
| Additional information: | This is the peer reviewed version of the following article: Tiss, A; Smith, C; Menon, U; Jacobs, I; Timms, JF; Cramer, R; (2010) A well-characterised peak identification list of MALDI MS profile peaks for human blood serum. PROTEOMICS, 10 (18) 3388 - 3392., which has been published in final form at http://dx.doi.org/10.1002/pmic.201000100. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-820227.html). |
| Keywords: | MALDI, MS/MS peak identification, serum profiling, technology, mass spectrometry, pancreatic cancer, plasma proteome, ovarian cancer, proteins, peptides, biomarkers, enrichment, carcinoma, diagnosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer |
| URI: | https://discovery.ucl.ac.uk/id/eprint/138395 |
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