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Myocardial ischemia-reperfusion injury: a neglected therapeutic target

Hausenloy, DJ; Yellon, DM; (2013) Myocardial ischemia-reperfusion injury: a neglected therapeutic target. Journal of Clinical Investigation , 123 (1) pp. 92-100. 10.1172/JCI62874. Green open access

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Abstract

Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI.

Type: Article
Title: Myocardial ischemia-reperfusion injury: a neglected therapeutic target
Open access status: An open access version is available from UCL Discovery
DOI: 10.1172/JCI62874
Publisher version: http://dx.doi.org/10.1172/JCI62874
Language: English
Additional information: Copyright © 2013, The American Society for Clinical Investigation.
Keywords: science & technology, life sciences & biomedicine, medicine, research & experimental, research & experimental medicine, medicine, research & experimental, percutaneous coronary intervention, mitochondrial permeability transition, randomized controlled-trial, left-ventricular function, reduces infarct size, no-reflow phenomenon, cardiovascular magnetic-resonance, glucose-insulin-potassium, microvascular obstruction, prognostic-significance
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/1382902
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