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Cardioprotection Techniques: Preconditioning, Postconditioning and Remote Con-ditioning (Basic Science)

Hausenloy, DJ; (2013) Cardioprotection Techniques: Preconditioning, Postconditioning and Remote Con-ditioning (Basic Science). Current Pharmaceutical Design , 19 (25) pp. 4544-4563. 10.2174/1381612811319250004. Green open access

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Abstract

Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. The major pathological consequences of IHD arise from the detrimental effects of acute ischemia-reperfusion injury (IRI) on the myocardium. Therefore, in order to improve clinical outcomes in patients with IHD, novel therapeutic strategies are required to protect the myocardium from acute IRI and preserve cardiac function (cardioprotection). In this regard, endogenous cardioprotective strategies such as ischemic preconditioning (IPC), ischemic postconditioning (IPost) and remote ischemic conditioning (RIC) may provide novel approaches for protecting the heart in clinical settings in which the patient experiences acute myocardial IRI. In this review article, we provide an overview of these endogenous cardioprotective strategies with respect to the pre-clinical experimental literature, exploring their major characteristics and underlying signaling mechanisms. The application of these therapeutic strategies in the clinical setting for potential patient benefit is reviewed in another article in this special issue.

Type: Article
Title: Cardioprotection Techniques: Preconditioning, Postconditioning and Remote Con-ditioning (Basic Science)
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.2174/1381612811319250004
Publisher version: http://dx.doi.org/10.2174/1381612811319250004
Language: English
Additional information: Copyright © 2013 Bentham Science Publishers. This article is available to download for free under the Open Access Plus program of Bentham Science in which the content is published under the creative commons license CC BY–NC–ND 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Cardiotonic Agents, Humans, Ischemic Preconditioning, Myocardial, Myocardial Ischemia, ischemic postconditioning, remote ischemic conditioning, cardioprotection, ischemia-reperfusion injury
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/1381437
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