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Glimepiride treatment facilitates ischemic preconditioning in the diabetic heart.

Hausenloy, DJ; Wynne, AM; Mocanu, MM; Yellon, DM; (2013) Glimepiride treatment facilitates ischemic preconditioning in the diabetic heart. J Cardiovasc Pharmacol Ther , 18 (3) 263 - 269. 10.1177/1074248412468945. Green open access

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Abstract

The diabetic heart is resistant to the myocardial infarct-limiting effects of ischemic preconditioning (IPC). This may be in part due to the downregulation of the phosphatidylinositol 3'-kinase-Akt pathway, an essential component of IPC protection. We hypothesized that treating the diabetic heart with the sulfonylurea, glimepiride, which has been reported to activate Akt, may lower the threshold required to protect the diabetic heart by IPC.

Type: Article
Title: Glimepiride treatment facilitates ischemic preconditioning in the diabetic heart.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1074248412468945
Publisher version: http://dx.doi.org/10.1177/1074248412468945
Language: English
Additional information: © The Author(s) 2012. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm).
Keywords: Animals, Cardiotonic Agents, Combined Modality Therapy, Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies, Enzyme Activators, Heart, Hemoglobin A, Glycosylated, Hyperglycemia, Hypoglycemic Agents, Ischemic Preconditioning, Myocardial, Myocardial Infarction, Myocardial Reperfusion Injury, Myocardium, Perfusion, Proto-Oncogene Proteins c-akt, Random Allocation, Rats, Rats, Inbred Strains, Sulfonylurea Compounds
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/1381432
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