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Phytochemical and biological investigation of Begonia heracleifolia

Frei, B; Heinrich, M; Herrmann, D; Orjala, JE; Schmitt, J; Sticher, O; (1998) Phytochemical and biological investigation of Begonia heracleifolia. Planta Medica , 64 (4) pp. 385-386. 10.1055/s-2006-957460.

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Abstract

From the rhizomes of Begonia heracleifolia six known cucurbitacins (1-6) were isolated. Based on spectral data (1D and 2D 1 H-, 13 C-NMR, ESI- and CI- MS) the structures were established as cucurbitacin B (1), cucurbitacin D (2), 23,24-dihydrocucurbitacin D (3), 23,24-dihydrocucurbitacin F (4), 2-O-β- glucopyranosyl-cucurbitacin B (5), and 2-O-β-glucopyranosyl-cucurbitacin D (6). Four of them (3-6) were so far not reported as constituents of Begonia spp. Varyingly strong antiproliferative activity towards tumor and immune cells was observed for three compounds (1-3), due to different structural features.

Type: Article
Title: Phytochemical and biological investigation of Begonia heracleifolia
DOI: 10.1055/s-2006-957460
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: http://discovery.ucl.ac.uk/id/eprint/1381129
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