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Data Resource Profile: Cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER)

Denaxas, SC; George, J; Herrett, E; Shah, AD; Kalra, D; Hingorani, AD; Kivimaki, M; ... Hemingway, H; + view all (2012) Data Resource Profile: Cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER). International Journal of Epidemiology , 41 (6) pp. 1625-1638. 10.1093/ije/dys188. Gold open access

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Abstract

The goal of cardiovascular disease (CVD) research using linked bespoke studies and electronic health records (CALIBER) is to provide evidence to inform health care and public health policy for CVDs across different stages of translation, from discovery, through evaluation in trials to implementation, where linkages to electronic health records provide new scientific opportunities. The initial approach of the CALIBER programme is characterized as follows: (i) Linkages of multiple electronic heath record sources: examples include linkages between the longitudinal primary care data from the Clinical Practice Research Datalink, the national registry of acute coronary syndromes (Myocardial Ischaemia National Audit Project), hospitalization and procedure data from Hospital Episode Statistics and cause-specific mortality and social deprivation data from the Office of National Statistics. Current cohort analyses involve a million people in initially healthy populations and disease registries with ∼105 patients. (ii) Linkages of bespoke investigator-led cohort studies (e.g. UK Biobank) to registry data (e.g. Myocardial Ischaemia National Audit Project), providing new means of ascertaining, validating and phenotyping disease. (iii) A common data model in which routine electronic health record data are made research ready, and sharable, by defining and curating with meta-data >300 variables (categorical, continuous, event) on risk factors, CVDs and non-cardiovascular comorbidities. (iv) Transparency: all CALIBER studies have an analytic protocol registered in the public domain, and data are available (safe haven model) for use subject to approvals. For more information, e-mail s.denaxas@ucl.ac.uk

Type: Article
Title: Data Resource Profile: Cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER)
Open access status: An open access publication
DOI: 10.1093/ije/dys188
Publisher version: http://dx.doi.org/ 10.1093/ije/dys188
Language: English
Additional information: © Copyright the Author 2012; all rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
Keywords: Electronic Health Records, Linkages, Cardiovascular, Cohort, Clopidogrel, Risk, Associations, Network
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > Epidemiology and Public Health
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > CHIME
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URI: http://discovery.ucl.ac.uk/id/eprint/1380673
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