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The relationship of gap junctions and compaction in the preimplantation mouse embryo.

Becker, DL; Leclerc-David, C; Warner, A; (1992) The relationship of gap junctions and compaction in the preimplantation mouse embryo. Dev Suppl pp. 113-118.

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Abstract

In the mouse embryo, gap junctions first appear at the 8-cell stage as compaction is about to take place. Compaction of the embryo is important for the differentiation of the first two cell types; the inner cell mass and the trophectoderm. Our studies examine the contribution of gap junctional communication at this stage of development. We have characterised the normal sequence of appearance of gap junction protein and its distribution. The extent of communication as shown by the passage of dye between cells has been recorded in both normal embryos and embryos treated with drugs that influence gap junctional communication. Comparisons have been made with embryos that express a lethal gap junction defect and attempts were made to rescue such embryos by increasing their gap junction communication.

Type: Article
Title: The relationship of gap junctions and compaction in the preimplantation mouse embryo.
Location: England
Keywords: Animals, Blastocyst, Cell Communication, Connexins, Intercellular Junctions, Membrane Proteins, Mice, Microscopy, Fluorescence
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/138009
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