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Leucine and tryptophan metabolism in rats

Salter, M; Bender, DA; Pogson, CI; (1985) Leucine and tryptophan metabolism in rats. Biochemical Journal , 225 (2) pp. 277-81.

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Abstract

The rate of tryptophan metabolism in isolated liver cells from animals fed on a high-leucine diet was greater than for cells from control animals. Leucine inhibited tryptophan metabolism and tryptophan uptake in isolated liver cells, probably by competing for membrane transport. Leucine had no effect on tryptophan 2,3-dioxygenase in vitro. 4-Methyl-2-oxovalerate increased tryptophan oxidation in incubations containing albumin, by displacing bound tryptophan and increasing the availability of the amino acid to the cell. The results suggest that, under extreme conditions, when the availability of tryptophan is low, leucine may be pellagragenic.

Type: Article
Title: Leucine and tryptophan metabolism in rats
Additional information: 0264-6021 (Print)In VitroJournal ArticleResearch Support, Non-U.S. Gov't
Keywords: Animals, Leucine, metabolism, pharmacology, Liver, cytology, drug effects, Male, Rats, Inbred Strains, Tryptophan, Tryptophan Oxygenase
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/137827
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