Lutti, A;
Thomas, DL;
Hutton, C;
Weiskopf, N;
(2013)
High-resolution functional MRI at 3 T: 3D/2D echo-planar imaging with optimized physiological noise correction.
Magn Reson Med
, 69
(6)
1657 - 1664.
10.1002/mrm.24398.
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Abstract
High-resolution functional MRI (fMRI) offers unique possibilities for studying human functional neuroanatomy. Although high-resolution fMRI has proven its potential at 7 T, most fMRI studies are still performed at rather low spatial resolution at 3 T. We optimized and compared single-shot two-dimensional echo-planar imaging (EPI) and multishot three-dimensional EPI high-resolution fMRI protocols. We extended image-based physiological noise correction from two-dimensional EPI to multishot three-dimensional EPI. The functional sensitivity of both acquisition schemes was assessed in a visual fMRI experiment. The physiological noise correction increased the sensitivity significantly, can be easily applied, and requires simple recordings of pulse and respiration only. The combination of three-dimensional EPI with physiological noise correction provides exceptional sensitivity for 1.5 mm high-resolution fMRI at 3 T, increasing the temporal signal-to-noise ratio by more than 25% compared to two-dimensional EPI.
| Type: | Article |
|---|---|
| Title: | High-resolution functional MRI at 3 T: 3D/2D echo-planar imaging with optimized physiological noise correction. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.24398 |
| Publisher version: | http://dx.doi.org/10.1002/mrm.24398 |
| Language: | English |
| Additional information: | © 2012 Wiley Periodicals, Inc. Full text made available to UCL Discovery by kind permission of Wiley. |
| Keywords: | Adult, Algorithms, Artifacts, Brain, Brain Mapping, Echo-Planar Imaging, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Imaging, Three-Dimensional, Male, Reproducibility of Results, Sensitivity and Specificity, Signal-To-Noise Ratio |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1377788 |
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