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Transbronchial biopsies in children after heart-lung transplantation.

Scott, JP; Higenbottam, TW; Smyth, RL; Whitehead, B; Helms, P; Fradet, G; De Leval, M; (1990) Transbronchial biopsies in children after heart-lung transplantation. Pediatrics , 86 (5) 698 - 702.

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Sixty transbronchial biopsies have been performed in eight children after heart-lung transplantation. The selection of fiber-optic bronchoscope or a small (4 mm; 30 cm) rigid bronchoscope was made according to the size of endotracheal tube required at surgery. If the endotracheal tube was size 7.5 or greater, a fiber-optic bronchoscope was used, whereas if the endotracheal tube size was below 7, a rigid bronchoscope was used. For the diagnosis of lung rejection, the histology of biopsies revealed a sensitivity of 91% and specificity of 69% (similar to the result in adults). The histology also distinguished lung infection from rejection. Complications included three pneumothoraces and two clinically significant episodes of hemorrhage, one of which led to a cardiorespiratory arrest, which may have been caused by hypoxia. As a result, arterial oxygen saturation is now monitored during the procedure using a pulse oximeter.

Type: Article
Title: Transbronchial biopsies in children after heart-lung transplantation.
Language: English
Keywords: Adolescent, Biopsy, Bronchi, Bronchoscopes, Bronchoscopy, Child, Child, Preschool, Diagnosis, Differential, Female, Forced Expiratory Volume, Graft Rejection, Heart Arrest, Heart-Lung Transplantation, Hemorrhage, Humans, Incidence, Lung Diseases, Male, Opportunistic Infections, Pneumonia, Pneumothorax, Sensitivity and Specificity, Time Factors
URI: http://discovery.ucl.ac.uk/id/eprint/1377424
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