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[Clinical applications of the heart-lung transplant. Clinical results 5 years after the start of the program at Papworth].

Fabbri, A; Scott, J; McGoldrick, J; Smyth, R; Fradet, G; Higenbottam, T; De Leval, M; (1989) [Clinical applications of the heart-lung transplant. Clinical results 5 years after the start of the program at Papworth]. G Ital Cardiol , 19 (11) pp. 989-998.

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Abstract

In this study is reviewed the experience at Papworth Hospital, Cambridgeshire, and Great Ormond Street Hospital, London, with combined heart-lung transplantation. Between April 1984 and June 1989, 73 patients have undergone heart-lung transplantation. Donors and recipients were carefully matched with regards to serology, morphology and cytomegalovirus compatibility. Heart preservation was based on use of cold St. Thomas' cardioplegic solution; a pulmonary preservation fluid has been developed that allows distant organ procurement with a single pulmonary artery flush technique (Papworth solution). The recipients were: 21 pts with Eisenmenger's syndrome, 15 pts with pulmonary hypertension, 37 pts with pulmonary disease (including 22 cystic fibrosis). The results are: no surgical mortality; no acute cardiac rejection episodes. Twenty-three patients died (16 with infections, 3 with obliterative bronchiolitis, 2 with cerebral embolism and 2 others). The actuarial survival rate at one year is 73.2%; 63% at two years and 47.4% at four years. The use of transbronchial biopsy of the lung has provided accurate early and safe diagnosis of pulmonary rejection. Development in organ preservation and patient management, as well as careful selection of recipients and donors, have led to the effective use of resources and thereby to these good results.

Type: Article
Title: [Clinical applications of the heart-lung transplant. Clinical results 5 years after the start of the program at Papworth].
Location: Italy
Keywords: Adolescent, Adult, Child, Child, Preschool, Cystic Fibrosis, Eisenmenger Complex, England, Evaluation Studies as Topic, Female, Follow-Up Studies, Heart-Lung Transplantation, Humans, Hypertension, Pulmonary, Male, Middle Aged
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Infect, Imm, Infla. and Physio Med
URI: http://discovery.ucl.ac.uk/id/eprint/1377404
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