Kumar, A;
Brockes, JP;
(2012)
Nerve dependence in tissue, organ, and appendage regeneration.
Trends Neurosci
, 35
(11)
691 - 699.
10.1016/j.tins.2012.08.003.
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Abstract
Many regeneration contexts require the presence of regenerating nerves as a transient component of the progenitor cell niche. Here we review nerve involvement in regeneration of various structures in vertebrates and invertebrates. Nerves are also implicated as persistent determinants in the niche of certain stem cells in mammals, as well as in Drosophila. We consider our present understanding of the cellular and molecular mechanisms underlying nerve dependence, including evidence of critical interactions with glia and non-neural cell types. The example of the salamander aneurogenic limb illustrates that developmental interactions between the limb bud and its innervation can be determinative for adult regeneration. These phenomena provide a different perspective on nerve cells to that based on chemical and electrical excitability.
| Type: | Article |
|---|---|
| Title: | Nerve dependence in tissue, organ, and appendage regeneration. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tins.2012.08.003 |
| Publisher version: | http://dx.doi.org/10.1016/j.tins.2012.08.003 |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Animals, Axons, Axotomy, Denervation, Drosophila melanogaster, Ear, External, Extremities, Fishes, Hydra, Invertebrates, Mice, Mice, Inbred Strains, Organ Specificity, Peripheral Nerves, Planarians, Regeneration, Schwann Cells, Species Specificity, Tail, Urodela, Vertebrates, Xenopus laevis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1377322 |
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