UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

How inositol pyrophosphates control cellular phosphate homeostasis?

Saiardi, A; (2012) How inositol pyrophosphates control cellular phosphate homeostasis? Advances in Biological Regulation , 52 (2) 351 - 359. 10.1016/j.jbior.2012.03.002. Green open access

[thumbnail of 1377309.pdf]
Preview
PDF
1377309.pdf

Download (303kB)

Abstract

Phosphorus in his phosphate PO(4)(3-) configuration is an essential constituent of all life forms. Phosphate diesters are at the core of nucleic acid structure, while phosphate monoester transmits information under the control of protein kinases and phosphatases. Due to these fundamental roles in biology it is not a surprise that phosphate cellular homeostasis is under tight control. Inositol pyrophosphates are organic molecules with the highest proportion of phosphate groups, and they are capable of regulating many biological processes, possibly by controlling energetic metabolism and adenosine triphosphate (ATP) production. Furthermore, inositol pyrophosphates influence inorganic polyphosphates (polyP) synthesis. The polymer polyP is solely constituted by phosphate groups and beside other known functions, it also plays a role in buffering cellular free phosphate [Pi] levels, an event that is ultimately necessary to generate ATP and inositol pyrophosphate. Although it is not yet clear how inositol pyrophosphates regulate cellular metabolism, understanding how inositol pyrophosphates influence phosphates homeostasis will help to clarify this important link. In this review I will describe the recent literature on this topic, with in the hope of inspiring further research in this fascinating area of biology.

Type: Article
Title: How inositol pyrophosphates control cellular phosphate homeostasis?
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jbior.2012.03.002
Publisher version: http://dx.doi.org/10.1016/j.jbior.2012.03.002
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Acid Anhydride Hydrolases, Animals, Homeostasis, Humans, Inositol Phosphates, Models, Biological, Phosphates, Phosphotransferases (Phosphate Group Acceptor), Polyphosphates, Pyrophosphatases
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1377309
Downloads since deposit
400Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item