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PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response

Shepherd, C; Banerjee, L; Cheung, CW; Mansour, MR; Jenkinson, S; Gale, RE; Khwaja, A; (2013) PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response. LEUKEMIA , 27 (3) pp. 650-660. 10.1038/leu.2012.285.

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Type: Article
Title: PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response
DOI: 10.1038/leu.2012.285
Keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Hematology, PI3K, NOTCH, c-MYC, T-cell, ACUTE LYMPHOBLASTIC-LEUKEMIA, T-CELL LEUKEMIA, GAMMA-SECRETASE INHIBITORS, PI3K INHIBITORS, C-MYC, PHOSPHATIDYLINOSITOL 3-KINASE, PHOSPHOINOSITIDE 3-KINASE, MAMMALIAN TARGET, MTOR INHIBITORS, DOWN-REGULATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1377202
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