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Investigations on karyotype evolution in patients with chronic myeloid leukemia (CML).

Haas, OA; Schwarzmeier, JD; Nacheva, E; Fischer, P; Paietta, E; (1984) Investigations on karyotype evolution in patients with chronic myeloid leukemia (CML). Blut , 48 (1) pp. 33-43.

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Abstract

In an attempt to relate karyotype evolution to clinical and hematological data serial chromosomal analyses were performed in 31 patients with chronic myeloid leukemia (CML), both in chronic and acute phases. Our results in Philadelphia chromosome (Ph1)-positive CML are in line with karyotype profiles described in the literature. In addition, we report on chromosomal findings in 4 cases of Ph1-negative disease, one presenting with an iso17q chromosome in the positive CML. The same chromosomal abnormality was observed in a small population of Ph1-negative cells present in one of two patients with mixed Ph1-positive/Ph1-negative CML. The first case of a female patient with the loss of a sex chromosome in Ph1-positive cells is reported. Two patients with unusually long and mild chronic phases despite the presence of trisomy 8 in their karyotypes are described. Our findings suggest that the order of appearance of additional chromosomal changes of CML is of prognostic significance for the progression and the clinical picture of the disease.

Type: Article
Title: Investigations on karyotype evolution in patients with chronic myeloid leukemia (CML).
Location: Germany
Keywords: Adult, Aged, Chromosome Aberrations, Chromosomes, Human, 21-22 and Y, Female, Humans, Hydroxyurea, Karyotyping, Leukemia, Myeloid, Male, Middle Aged, X Chromosome
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
URI: http://discovery.ucl.ac.uk/id/eprint/1376436
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