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Interleukin-6 receptor pathways in abdominal aortic aneurysm

Harrison, SC; Smith, AJ; Jones, GT; Swerdlow, DI; Rampuri, R; Bown, MJ; Aneurysm Consortium, ; ... Humphries, SE; + view all (2013) Interleukin-6 receptor pathways in abdominal aortic aneurysm. European Heart Journal , 34 (48) , Article ehs354v1. 10.1093/eurheartj/ehs354. Green open access

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Abstract

We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo. Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach.

Type: Article
Title: Interleukin-6 receptor pathways in abdominal aortic aneurysm
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/eurheartj/ehs354
Publisher version: http://dx.doi.org/10.1093/eurheartj/ehs354
Language: English
Additional information: © The Author 2012. Published by Oxford University Press on behalf of European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oup.com.
Keywords: Abdominal aortic aneurysm, Interleukin-6, Mendelian randomization, Polymorphism
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics > Clinical Epidemiology
URI: http://discovery.ucl.ac.uk/id/eprint/1375806
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