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Schistosoma mansoni: effects on tryptophan metabolism in mice

Njagi, EN; Bender, DA; (1990) Schistosoma mansoni: effects on tryptophan metabolism in mice. Experimental Parasitology , 70 (1) pp. 43-54.

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Abstract

In mice, infection with 20-30 cercariae of Schistosoma mansoni resulted in a considerable reduction in the formation of 14CO2 from [14C]tryptophan. Infected animals excreted significantly lower amounts of kynurenine, kynurenic acid, and methyl pyridone carboxamide than did uninfected controls. There was no difference in the ability of hepatocytes isolated from infected or control animals to metabolise [14C]tryptophan. Hepatocytes from infected animals synthesized less NAD(P), but more niacin and N1-methyl nicotinamide from tryptophan. They showed no greater accumulation of kynurenine metabolites than did cells from control animals. The hepatocyte content of pyridoxal phosphate and the erythrocyte aspartate aminotransferase activation coefficient were the same in both groups of mice, suggesting that infection with S. mansoni does not deplete vitamin B6. The impairment of tryptophan metabolism in vivo was apparently not due to impaired hepatic metabolism. Rather, it seems likely that the parasites or their eggs take up tryptophan avidly from the host's circulation. Studies of parasite and egg metabolism of tryptophan may suggest novel approaches to the chemotherapy of bilharzia.

Type: Article
Title: Schistosoma mansoni: effects on tryptophan metabolism in mice
Additional information: 0014-4894 (Print)Journal ArticleResearch Support, Non-U.S. Gov't
Keywords: Animals, Chemistry, Kynurenic Acid, urine, Kynurenine, Liver, parasitology, Male, Mice, Niacinamide, analogs & derivatives, Oxidation-Reduction, Pyridoxine, analysis, Schistosomiasis mansoni, metabolism, Tryptophan, blood
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/137501
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