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An echocardiographic left ventricular wall area index for functional detection of myocardial injury in hemodynamically unloaded hearts.

Gilman, G; Hansen, WH; Hagen, ME; Rosales, AG; Bailey, KR; McGregor, CGA; Belohlavek, M; (2006) An echocardiographic left ventricular wall area index for functional detection of myocardial injury in hemodynamically unloaded hearts. Echocardiography , 23 (1) pp. 7-13. 10.1111/j.1540-8175.2005.00161.x.

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Abstract

Functional assessment of the left ventricle is affected by loading conditions. Detection of rejection-mediated myocardial injury in a heterotopic heart transplant model is a challenge for the echocardiographer because the heart is in an unloaded state. We examined the relationship of a novel left ventricular (LV) wall area index (LVWAI) and serum cardiac troponin T (cTnT) levels. The LVWAI, based on prior methods of determining LV mass, was defined as the difference between epicardial and endocardial areas divided by the epicardial area. The biphasic morphometric response of LVWAI reflected changes in the cTnT levels and allowed echocardiographic detection of myocardial injury in hemodynamically unloaded hearts.

Type: Article
Title: An echocardiographic left ventricular wall area index for functional detection of myocardial injury in hemodynamically unloaded hearts.
Location: United States
DOI: 10.1111/j.1540-8175.2005.00161.x
Keywords: Animals, Animals, Genetically Modified, Disease Models, Animal, Echocardiography, Endocardium, Graft Rejection, Heart Transplantation, Hemodynamics, Humans, Organ Size, Papio anubis, Pericardium, Severity of Illness Index, Sus scrofa, Transplantation, Heterologous, Troponin T, Ventricular Dysfunction, Left
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/1373695
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