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Azabicyclic indole esters as potent 5-HT4 receptor antagonists.

Wyman, PA; Gaster, LM; King, FD; Sutton, JM; Ellis, ES; Wardle, KA; Young, TJ; (1996) Azabicyclic indole esters as potent 5-HT4 receptor antagonists. Bioorg Med Chem , 4 (2) pp. 255-261.

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Abstract

The synthesis of a series of azabicyclic indole esters is described and their potency reported as 5-HT4 receptor antagonists. Optimization of the most potent compound (19) by preparing the corresponding oxazino[3,2-a]indole ester afforded 34, which had a pIC50 of 9.5 in the guinea pig distal colon longitudinal muscle myenteric plexus preparation.

Type: Article
Title: Azabicyclic indole esters as potent 5-HT4 receptor antagonists.
Location: ENGLAND
Keywords: Animals, Colon, Guinea Pigs, In Vitro Techniques, Indoles, Myenteric Plexus, Receptors, Serotonin, Receptors, Serotonin, 5-HT4, Serotonin Antagonists, Stereoisomerism, Structure-Activity Relationship
UCL classification: UCL > School of BEAMS > Faculty of Maths and Physical Sciences
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
URI: http://discovery.ucl.ac.uk/id/eprint/1373418
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