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Poor outcome of central nervous system invasive aspergillosis in HIV infection despite galactomannan-based diagnosis: A case series and literature review

Khan, AB; Lipman, M; Hopkins, S; Marshall, N; Galloway, M; Kibbler, C; (2011) Poor outcome of central nervous system invasive aspergillosis in HIV infection despite galactomannan-based diagnosis: A case series and literature review. Infectious Diseases in Clinical Practice , 19 (4) pp. 299-302. 10.1097/IPC.0b013e3182041769.

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Abstract

Invasive aspergillosis is recognized as a devastating disease in some immunocompromised populations, although it is not accepted as an established complication of human immunodeficiency virus/acquired immunodeficiency syndrome under the World Health Organization's staging criteria. Complications affecting the central nervous system are rarely reported, which may relate to a lack of adequate diagnostic tests. We report the use of the galactomannan Platelia assay in 3 patients with invasive cerebral infection and advanced human immunodeficiency virus, as defined by the World Health Organization, with CD4 T-lymphocyte counts of less than 350 cells/μL. The clinical use of the assay in early detection, particularly when used in a serial fashion, is compared to standard microbiological techniques. The limitations of the current assay are described in the context of future diagnostic approaches, such as sampling of cerebrospinal fluid and bronchoalveolar lavage specimens and the use of nucleic acid techniques. Copyright © 2011 by National Foundation for Infectious Diseases.

Type: Article
Title: Poor outcome of central nervous system invasive aspergillosis in HIV infection despite galactomannan-based diagnosis: A case series and literature review
DOI: 10.1097/IPC.0b013e3182041769
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/1372673
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