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A PLACEBO-CONTROLLED TRIAL OF ISOPRINOSINE IN PATIENTS WITH MULTIPLE-SCLEROSIS

MILLIGAN, NM; MILLER, DH; COMPSTON, DAS; (1994) A PLACEBO-CONTROLLED TRIAL OF ISOPRINOSINE IN PATIENTS WITH MULTIPLE-SCLEROSIS. J NEUROL NEUROSUR PS , 57 (2) 164 - 168.

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Abstract

Isoprinosine was used double-blind, randomised, placebo-controlled conditions in 52 patients with relapsing/remitting or progressive multiple sclerosis. Ah patients received pulsed treatment with methylprednisolone. There was no significant effect of treatment on clinical disability or the accumulation of MRI abnormalities, after correction of results for multiple comparisons. It is concluded that isoprinosine is not effective therapy for multiple sclerosis.

Type: Article
Title: A PLACEBO-CONTROLLED TRIAL OF ISOPRINOSINE IN PATIENTS WITH MULTIPLE-SCLEROSIS
Keywords: BLIND CONTROLLED TRIAL, INOSINE PRANOBEX, INTERLEUKIN-2 PRODUCTION, METHYLPREDNISOLONE, AZATHIOPRINE, EFFICACY, CYCLOSPORINE, GUIDELINES, INVITRO, ACTH
URI: http://discovery.ucl.ac.uk/id/eprint/137177
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