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The effect of ethanol on glucose production in phosphorylase b kinase deficiency.

Collins, JE; Bartlett, K; Leonard, JV; Aynsley-Green, A; (1989) The effect of ethanol on glucose production in phosphorylase b kinase deficiency. J Inherit Metab Dis , 12 (3) pp. 317-322.

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Abstract

Glucose production was measured using stable isotopic techniques in two patients with phosphorylase b kinase deficiency before and after oral ethanol (0.75 g/kg). Glucose production was normal before the ethanol. In one patient, who did not take the full dose of ethanol, glucose production rose initially and then fell. In the other, glucose production fell steadily and in both patients blood lactate concentrations rose. Blood glucose concentrations decreased. Patients with this enzyme deficiency are dependent on the gluconeogenic pathway when fasting and, therefore, ethanol may be potentially hazardous.

Type: Article
Title: The effect of ethanol on glucose production in phosphorylase b kinase deficiency.
Location: United States
Keywords: Adolescent, Alcohol Drinking, Blood Glucose, Ethanol, Gluconeogenesis, Humans, Kinetics, Lactates, Male, Phosphorylase Kinase, Phosphorylase b, Phosphorylases
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Infect, Imm, Infla. and Physio Med
URI: http://discovery.ucl.ac.uk/id/eprint/1371476
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