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Value of the glucagon test in screening for hepatic glycogen storage disease.

Dunger, DB; Leonard, JV; (1982) Value of the glucagon test in screening for hepatic glycogen storage disease. Arch Dis Child , 57 (5) pp. 384-389. 10.1136/adc.57.5.384.

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Abstract

The fasting glucagon test of 40 patients with hepatic glycogen storage disease (type I, 13 patients; type Ib, 5 patients; type III, 12 patients; type IX (phosphorylase kinase deficiency), 10 patients) has been reviewed. In all patients with types Ib and III the blood glucose level rose less than 1 mmol/1 but in types 1 and IX there was wide variation in response. Blood lactate levels were greater than 2.4 mmol/1 in all patients with type I and Ib 120 minutes after the administration of glucagon but were lower than 2.4 mmol/1 in types III and IX. The value of this test for screening was analysed using several criteria. From the data a simplified scheme for the investigation of patients with suspected hepatic glycogen storage disease is proposed.

Type: Article
Title: Value of the glucagon test in screening for hepatic glycogen storage disease.
Location: England
DOI: 10.1136/adc.57.5.384
Keywords: Blood Glucose, Fasting, Glucagon, Glycogen Storage Disease, Humans, Lactates, Lactic Acid, Liver Diseases
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Infect, Imm, Infla. and Physio Med
URI: http://discovery.ucl.ac.uk/id/eprint/1371424
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