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Long-term follow-up of children with familial hypercholesterolaemia treated with cholestyramine.

West, RJ; Lloyd, JK; Leonard, JV; (1980) Long-term follow-up of children with familial hypercholesterolaemia treated with cholestyramine. Lancet , 2 (8200) pp. 873-875.

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Abstract

35 children with the heterozygous form of familial hypercholesterolaemia (FH) who were followed for up to 8 years after starting on cholestyramine treatment showed a progressive decrease in compliance with therapy with time, so that only 55% remained on treatment after 6 years and only 48% after 8 years. Long-term compliance was significantly better in those starting treatment before age 10. Plasma-cholesterol was lowered in all children taking cholestyramine: for the group the mean reduction in plasma-cholesterol ranged from 26 to 44% during the years of the study, on a mean cholestyramine dose of around 0.4 g/kg/day. Cholestyramine thus effectively lowers plasma-cholesterol in FH, but for long-term use compliance is a problem in many children.

Type: Article
Title: Long-term follow-up of children with familial hypercholesterolaemia treated with cholestyramine.
Location: England
Keywords: Adolescent, Age Factors, Child, Child, Preschool, Cholesterol, Cholestyramine Resin, Female, Follow-Up Studies, Heterozygote, Humans, Hyperlipoproteinemia Type II, Infant, Lipoproteins, LDL, Male, Patient Compliance, Time Factors
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health
URI: http://discovery.ucl.ac.uk/id/eprint/1371419
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