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Familial insulin resistance with pineal hyperplasia: metabolic studies and effect of hypophysectomy.

West, RJ; Leonard, JV; (1980) Familial insulin resistance with pineal hyperplasia: metabolic studies and effect of hypophysectomy. Arch Dis Child , 55 (8) pp. 619-621.

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Abstract

Mendenhall's syndrome comprises insulin-resistant diabetes, pineal hyperplasia, and various somatic anomalies. A boy with this condition now aged 12 years is reported; a similarly affected sibling died aged 7.8 years. Hypophysectomy has been of short-term benefit, but the problems of insulin resistance persist. On the basis of monocyte-binding studies it seems likely that in this condition there is an inherited deficiency of insulin receptors.

Type: Article
Title: Familial insulin resistance with pineal hyperplasia: metabolic studies and effect of hypophysectomy.
Location: England
Keywords: Child, Diabetes Mellitus, Humans, Hyperplasia, Hypophysectomy, Insulin, Insulin Resistance, Male, Pineal Gland, Syndrome
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health
URI: http://discovery.ucl.ac.uk/id/eprint/1371418
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