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Effect of naloxone in a previously undescribed hypothalamic syndrome. A disorder of the endogenous opioid peptide system?

Dunger, DB; Leonard, JV; Wolff, OH; Preece, MA; (1980) Effect of naloxone in a previously undescribed hypothalamic syndrome. A disorder of the endogenous opioid peptide system? Lancet , 1 (8181) pp. 1277-1281.

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Abstract

A syndrome of disordered hypothalamic function with abnormal control of temperature, appetite, and thirst, hyperprolactinaemia, and inappropriate vasopressin release is described in a 13-year-old boy who, in addition, had insensitivity to pain and a more general disorder affecting mood, sleep, and control of respiration. A disturbance of the opioid peptide system is postulated. Naloxone reversed central analgesia, altered urine fluid and electrolyte excretion, modified the hormonal response to gonadotrophin-releasing and thyrotrophin-releasing hormones, and improved the auditory and visual reaction times. Specific opioid antagonists may have a therapeutic role.

Type: Article
Title: Effect of naloxone in a previously undescribed hypothalamic syndrome. A disorder of the endogenous opioid peptide system?
Location: England
Keywords: Adolescent, Appetite, Body Temperature, Child, Child, Preschool, Emotions, Endorphins, Humans, Hypothalamus, Inappropriate ADH Syndrome, Male, Naloxone, Pain Insensitivity, Congenital, Respiration, Sleep, Syndrome, Thirst
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health
URI: http://discovery.ucl.ac.uk/id/eprint/1371417
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