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A Simple Sign for Recognizing Off-Axis OCT Measurement Beam Placement in the Context of Multicentre Studies

Balk, LJ; de Vries-Knoppert, WA; Petzold, A; (2012) A Simple Sign for Recognizing Off-Axis OCT Measurement Beam Placement in the Context of Multicentre Studies. PLoS One , 7 (11) , Article e48222. 10.1371/journal.pone.0048222. Green open access

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Abstract

Optical coherence tomography (OCT) allows quantification of the thickness of the retinal nerve fibre layer (RNFL) thickness, a potential biomarker for neurodegeneration. The estimated annual RNFL loss in multiple sclerosis amounts to 2 μm using time domain OCT. The recognition of measurement artifacts exceeding this limit is relevant for the successful use of OCT as a secondary outcome measure in clinical trials.

Type: Article
Title: A Simple Sign for Recognizing Off-Axis OCT Measurement Beam Placement in the Context of Multicentre Studies
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0048222
Publisher version: http://dx.doi.org/10.1371/journal.pone.0048222
Language: English
Additional information: © 2012 Balk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3493550. Video S1: Live coverage of the effect of off axis measurement beam placement: This video shows the situation of off-centre beam placement, with the live OCT image in the acquisition window. This image shows the artifacts caused by temporal, nasal, inferior and superior off-centre placement of the measurement beam.(WMV)
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: http://discovery.ucl.ac.uk/id/eprint/1370629
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