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In Vitro Simulation and Validation of the Circulation with Congenital Heart Defects.

Figliola, RS; Giardini, A; Conover, T; Camp, TA; Biglino, G; Chiulli, J; Hsia, T-Y; (2010) In Vitro Simulation and Validation of the Circulation with Congenital Heart Defects. Prog Pediatr Cardiol , 30 (1-2) pp. 71-80. 10.1016/j.ppedcard.2010.09.009.

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Abstract

Despite the recent advances in computational modeling, experimental simulation of the circulation with congenital heart defect using mock flow circuits remains an important tool for device testing, and for detailing the probable flow consequences resulting from surgical and interventional corrections. Validated mock circuits can be applied to qualify the results from novel computational models. New mathematical tools, coupled with advanced clinical imaging methods, allow for improved assessment of experimental circuit performance relative to human function, as well as the potential for patient-specific adaptation. In this review, we address the development of three in vitro mock circuits specific for studies of congenital heart defects. Performance of an in vitro right heart circulation circuit through a series of verification and validation exercises is described, including correlations with animal studies, and quantifying the effects of circuit inertiance on test results. We present our experience in the design of mock circuits suitable for investigations of the characteristics of the Fontan circulation. We use one such mock circuit to evaluate the accuracy of Doppler predictions in the presence of aortic coarctation.

Type: Article
Title: In Vitro Simulation and Validation of the Circulation with Congenital Heart Defects.
Location: Netherlands
DOI: 10.1016/j.ppedcard.2010.09.009
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Congenital Heart Disease
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URI: http://discovery.ucl.ac.uk/id/eprint/1369148
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