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Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response.

Calcinaghi, N; Jolivet, R; Wyss, MT; Ametamey, SM; Gasparini, F; Buck, A; Weber, B; (2011) Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response. J Cereb Blood Flow Metab , 31 (9) e1-10. 10.1038/jcbfm.2011.96.

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Abstract

Activation of astrocytic metabotropic glutamate receptor 5 (mGluR5) is postulated to elicit calcium transients, triggering a chain of events that ultimately regulates cerebral blood flow by changing the tone of smooth muscle cells of nearby arterioles. Using concurrent in vivo optical imaging and determination of receptor occupancy with (11)C-ABP688, we report here that blocking ∼80% of mGluR5 in vivo does not affect transient hemodynamic responses on brief whisker stimulations while transiently reducing neuronal activity as measured by voltage-sensitive dye imaging. Our results show that mechanisms other than activation of mGluR5 are required to trigger the initial hemodynamic response in normal physiological conditions.

Type: Article
Title: Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response.
Location: United States
DOI: 10.1038/jcbfm.2011.96
Keywords: Animals, Cerebellar Cortex, Hemodynamics, Male, Neurons, Rats, Rats, Sprague-Dawley, Receptor, Metabotropic Glutamate 5, Receptors, Metabotropic Glutamate
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1368739
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