Cuttell, L and Vaughan, A and Silva, E and Escaron, CJ and Lavine, M and Van Goethem, E and Eid, JP and Quirin, M and Franc, NC (2008) Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis. Cell , 135 (3) 524 - 534. 10.1016/j.cell.2008.08.033.
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Phagocytosis is important during development and in the immune response for the removal of apoptotic cells and pathogens, yet its molecular mechanisms are poorly understood. In Caenorhabditis elegans, the CED2/5/10/12 pathway regulates actin during phagocytosis of apoptotic cells, whereas the role of the CED1/6/7 pathway in phagocytosis is unclear. We report that Undertaker (UTA), a Drosophila Junctophilin protein, is required for Draper (CED-1 homolog)-mediated phagocytosis. Junctophilins couple Ca2+ channels at the plasma membrane to those of the endoplasmic reticulum (ER), the Ryanodine receptors. We place Draper, its adaptor drCed-6, UTA, the Ryanodine receptor Rya-r44F, the ER Ca2+ sensor dSTIM, and the Ca2+-release-activated Ca2+ channel dOrai in the same pathway that promotes calcium homeostasis and phagocytosis. Thus, our results implicate a Junctophilin in phagocytosis and link Draper-mediated phagocytosis to Ca2+ homeostasis, highlighting a previously uncharacterized role for the CED1/6/7 pathway.
|Title:||Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis.|
|Keywords:||Animals, Animals, Genetically Modified, Apoptosis, Calcium, Drosophila Proteins, Drosophila melanogaster, Embryo, Nonmammalian, Membrane Proteins, Phagocytosis|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Laboratory for Molecular Cell Biology|
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