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The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila.

Chew, SK; Akdemir, F; Chen, P; Lu, W-J; Mills, K; Daish, T; Kumar, S; ... Abrams, JM; + view all (2004) The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev Cell , 7 (6) pp. 897-907. 10.1016/j.devcel.2004.09.016.

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Abstract

Among the seven caspases encoded in the fly genome, only dronc contains a caspase recruitment domain. To assess the function of this gene in development, we produced a null mutation in dronc. Animals lacking zygotic dronc are defective for programmed cell death (PCD) and arrest as early pupae. These mutants present a range of defects, including extensive hyperplasia of hematopoietic tissues, supernumerary neuronal cells, and head involution failure. dronc genetically interacts with the Ced4/Apaf1 counterpart, Dark, and adult structures lacking dronc are disrupted for fine patterning. Furthermore, in diverse models of metabolic injury, dronc- cells are completely insensitive to induction of cell killing. These findings establish dronc as an essential regulator of cell number in development and illustrate broad requirements for this apical caspase in adaptive responses during stress-induced apoptosis.

Type: Article
Title: The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila.
Location: United States
DOI: 10.1016/j.devcel.2004.09.016
Keywords: Alleles, Animals, Apoptosis, Body Patterning, Caspases, Cell Death, Drosophila Proteins, Drosophila melanogaster, Eye, Gene Expression Regulation, Developmental, Genetic Complementation Test, Genome, Genotype, Green Fluorescent Proteins, Hemocytes, Homozygote, Image Processing, Computer-Assisted, Immunohistochemistry, In Situ Nick-End Labeling, Models, Genetic, Mutagenesis, Mutation, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Time Factors
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/1367975
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