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Genetic and environmental factors in the cause of Parkinson's disease

Warner, TT; Schapira, AHV; (2003) Genetic and environmental factors in the cause of Parkinson's disease. ANN NEUROL , 53 S16 - S23. 10.1002/ana.10487.

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Abstract

Despite being the subject of intense study, the pathogenesis of Parkinson's disease still remains unclear. In recent years, however, there has been increasing evidence to support a role for genetic factors in its cause. This has come from twin and family studies, the mapping and cloning of PARK genes that are associated with the development of PD, and analysis of potential susceptibility genes. There is also evidence indicating that environmental factors may play a role in the disease process. It is likely that for most cases, there is a complex interplay between these genetic and environmental influences in the causation of Parkinson's disease. This article reviews the evidence in support of genetic and environmental factors in the cause of PD.

Type: Article
Title: Genetic and environmental factors in the cause of Parkinson's disease
DOI: 10.1002/ana.10487
Keywords: ALPHA-SYNUCLEIN GENE, SINGLE-NUCLEOTIDE POLYMORPHISMS, DOPAMINE-TRANSPORTER GENE, UBIQUITIN-PROTEIN LIGASE, MONOAMINE-OXIDASE-B, JUVENILE PARKINSONISM, ALLELIC ASSOCIATION, AUTOSOMAL-DOMINANT, CANDIDATE GENES, RISK-FACTOR
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/136764
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