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Contemporary approaches to protein structure classification

Swindells, MB; Orengo, CA; Jones, DT; Hutchinson, EG; Thornton, JM; (1998) Contemporary approaches to protein structure classification. BIOESSAYS , 20 (11) 884 - 891.

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Abstract

In a similar manner to sequence database searching, it is also possible to compare three-dimensional protein structures. Such methods can be extremely useful because a structural similarity may represent a distant evolutionary relationship that is undetectable by sequence analysis. In this review, we summarise the most popular structure comparison methods, show how they can be used for database searching, and then describe some of the most advanced attempts to develop comprehensive protein structure classifications. With such data, it is possible to identify distant evolutionary relationships, provide libraries of unique folds for structure prediction, estimate the total number of folds that exist, and investigate the preference for certain types of structures over others. (C) 1998 John Wiley & Sons, Inc.

Type:Article
Title:Contemporary approaches to protein structure classification
Keywords:REPLICATION TERMINATOR PROTEIN, STRUCTURE ALIGNMENT, CRYSTAL-STRUCTURE, FOLD RECOGNITION, HELIX PACKING, DATABASE, DOMAINS, IDENTIFICATION, SEQUENCES, SUBSTRUCTURES
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Structural and Molecular Biology
UCL > School of BEAMS > Faculty of Engineering Science > Computer Science

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