UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information.

Correia, T; Aguirre, J; Sisniega, A; Chamorro-Servent, J; Abascal, J; Vaquero, JJ; Desco, M; (2011) Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information. Biomed Opt Express , 2 (9) 2632 - 2648. 10.1364/BOE.2.002632. Gold open access

Abstract

Fluorescence diffuse optical tomography (fDOT) is an imaging modality that provides images of the fluorochrome distribution within the object of study. The image reconstruction problem is ill-posed and highly underdetermined and, therefore, regularisation techniques need to be used. In this paper we use a nonlinear anisotropic diffusion regularisation term that incorporates anatomical prior information. We introduce a split operator method that reduces the nonlinear inverse problem to two simpler problems, allowing fast and efficient solution of the fDOT problem. We tested our method using simulated, phantom and ex-vivo mouse data, and found that it provides reconstructions with better spatial localisation and size of fluorochrome inclusions than using the standard Tikhonov penalty term.

Type: Article
Title: Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information.
Location: United States
Open access status: An open access publication
DOI: 10.1364/BOE.2.002632
Language: English
Keywords: (100.3190) Inverse problems, (170.6960) Tomography
UCL classification: UCL > School of BEAMS > Faculty of Engineering Science > Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/1366611
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item