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Fetal haemoglobin and pregnancy in homozygous sickle cell disease

Dunn, DT; Poddar, D; Serjeant, BE; Serjeant, GR; (1989) Fetal haemoglobin and pregnancy in homozygous sickle cell disease. Br J Haematol , 72 (3) pp. 434-438.

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Abstract

The pregnancy related changes in fetal haemoglobin (HbF) have been observed in 152 pregnancies in 125 women with homozygous sickle cell (SS) disease and related to steady state levels in the same individual. Statistically significant increases in the first and second trimesters, were followed by significant falls below steady state levels in the third trimester and postpartum period. Although these corresponded to a mean increase of 0.7% and a mean decrease of 1.6%, much greater changes occurred in some individuals. Mean levels had not returned to steady state values 1 year after delivery. The hormonal changes in pregnancy appear to have profound effects on HbF level in SS disease, the mechanisms of which require further study.

Type: Article
Title: Fetal haemoglobin and pregnancy in homozygous sickle cell disease
Additional information: Dunn, D T Poddar, D Serjeant, B E Serjeant, G R England British journal of haematology Br J Haematol. 1989 Jul;72(3):434-8. The pregnancy related changes in fetal haemoglobin (HbF) have been observed in 152 pregnancies in 125 women with homozygous sickle cell (SS) disease and related to steady state levels in the same individual. Statistically significant increases in the first and second trimesters, were followed by significant falls below steady state levels in the third trimester and postpartum period. Although these corresponded to a mean increase of 0.7% and a mean decrease of 1.6%, much greater changes occurred in some individuals. Mean levels had not returned to steady state values 1 year after delivery. The hormonal changes in pregnancy appear to have profound effects on HbF level in SS disease, the mechanisms of which require further study.
Keywords: Anemia, Sickle Cell/ blood Female Fetal Hemoglobin/ analysis Humans Postpartum Period/blood Pregnancy Pregnancy Complications, Hematologic/ blood Time Factors
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: http://discovery.ucl.ac.uk/id/eprint/1366320
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