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Neural correlates of sad faces predict clinical remission to cognitive behavioural therapy in depression

Costafreda, SG; Khanna, A; Mourao-Miranda, J; Fu, CHY; (2009) Neural correlates of sad faces predict clinical remission to cognitive behavioural therapy in depression. NEUROREPORT , 20 (7) 637 - 641. 10.1097/WNR.0b013e3283294159.

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Abstract

Currently, there are no neurobiological markers of clinical response for cognitive behavioural therapy (CBT) used in clinical practice. We investigated the neural pattern of activity to implicit processing of sad facial expressions as a predictive marker of clinical response. Sixteen medication-free patients in an acute episode of major depression underwent functional magnetic resonance imaging scans before treatment with CBT. Nine patients showed a full clinical response. The pattern of activity, which predicted clinical response, was analysed with support vector machine and leave-one-out cross-validation. The functional neuroanatomy of sad faces at the lowest and highest intensities identified patients, before the initiation of therapy, who had a full clinical response to CBT (sensitivity 71%, specificity 86%, P = 0.029). NeuroReport 20:637-641 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Type:Article
Title:Neural correlates of sad faces predict clinical remission to cognitive behavioural therapy in depression
DOI:10.1097/WNR.0b013e3283294159
Keywords:clinical response, cognitive behavioural therapy, depression, facial expression, functional magnetic resonance imaging, predictors, sad faces, support vector machine, MAJOR DEPRESSION, ANTIDEPRESSANT TREATMENT, FACIAL EXPRESSIONS, RESPONSES, FMRI
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Computer Science

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