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Modified glycol chitosan nanocarriers carry hydrophobic materials into tumours

Raza, A; De La Fuente, M; Uchegbu, IF; Schätzlein, A; (2010) Modified glycol chitosan nanocarriers carry hydrophobic materials into tumours. Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 , 3 pp. 350-353.

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Abstract

Etoposide is a hydrophobic cytotoxic drug with activity in a range of cancers. In order to reduce side effects of the current formulation we have formulated the drug in nanosized carriers prepared from amphiphilic derivatives of glycol chitosan which dramatically improve bioavailability of hydrophobic drugs [1]. To this end a 13 kDa glycol chitosan was modified by palmitoylation and quaternisation. Micelles prepared from this polymer encapsulate up to 3.42 mg/ml etoposide. Using the hydrophobic fluorescent dye nile red we show that micelles efficiently deliver their payload to MCF-7 cancer cells in vitro and to A431 xenograft tumours in vivo, suggesting these systems could also deliver hydrophobic anti - cancer drugs such as eto poside to tumours.

Type: Article
Title: Modified glycol chitosan nanocarriers carry hydrophobic materials into tumours
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: http://discovery.ucl.ac.uk/id/eprint/1364986
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