Highton, D;
Panovska-Griffiths, J;
Ghosh, A;
Tachtsidis, I;
Banaji, M;
Elwell, C;
Smith, M;
(2013)
Modelling cerebrovascular reactivity: a novel near-infrared biomarker of cerebral autoregulation?
Adv Exp Med Biol
, 765
87 - 93.
10.1007/978-1-4614-4989-8_13.
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Abstract
Understanding changes in cerebral oxygenation, haemodynamics and metabolism holds the key to individualised, optimised therapy after acute brain injury. Near-infrared spectroscopy (NIRS) offers the potential for non-invasive, continuous bedside measurement of surrogates for these processes. Interest has grown in applying this technique to interpret cerebrovascular pressure reactivity (CVPR), a surrogate of the brain's ability to autoregulate blood flow. We describe a physiological model-based approach to NIRS interpretation which predicts autoregulatory efficiency from a model parameter k_aut. Data from three critically brain-injured patients exhibiting a change in CVPR were investigated. An optimal value for k_aut was determined to minimise the difference between measured and simulated outputs. Optimal values for k_aut appropriately tracked changes in CVPR under most circumstances. Further development of this technique could be used to track CVPR providing targets for individualised management of patients with altered vascular reactivity, minimising secondary neurological insults.
| Type: | Article |
|---|---|
| Title: | Modelling cerebrovascular reactivity: a novel near-infrared biomarker of cerebral autoregulation? |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-1-4614-4989-8_13 |
| Publisher version: | http://dx.doi.org/10.1007/978-1-4614-4989-8_13 |
| Language: | English |
| Additional information: | © Springer Science+Business Media New York 2013. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| Keywords: | Biological Markers, Brain, Brain Injuries, Cerebrovascular Circulation, Hemodynamics, Homeostasis, Humans, Monitoring, Physiologic, Oxidation-Reduction, Oxygen, Spectroscopy, Near-Infrared |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1364853 |
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