UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The functional anatomy of the MMN: A DCM study of the roving paradigm

Garrido, MI; Friston, KJ; Kiebel, SJ; Stephan, KE; Baldeweg, T; Kilner, JM; (2008) The functional anatomy of the MMN: A DCM study of the roving paradigm. NEUROIMAGE , 42 (2) 936 - 944. 10.1016/j.neuroimage.2008.05.018. Gold open access

Abstract

Using dynamic causal modelling (DCM), we have presented provisional evidence to Suggest: (i) the mismatch negativity (MMN) is generated by self-organised interactions within a hierarchy of cortical sources [Garrido, M.I., Kilner, J.M., Kiebel, S.J., Stephan, K.E., Friston, K.J., 2007. Dynamic causal modelling of evoked potentials: a reproducibility Study. NeuroImage 36, 571-580] and (ii) the MMN tests on plastic change in both extrinsic (between-source) and intrinsic (within Source) connections (Garrido et al., Under review). In this work we revisit these two key issues in the context of the roving paradigm. Critically, this paradigm allows Lis to discount any differential response to differences in the stimuli per se, because the standards and oddballs are physically identical. We were able to confirm both the hierarchical nature of the MMN generation and the conjoint role of changes in extrinsic and intrinsic connections. These findings are consistent with a predictive coding account of repetition-suppression and the MMN, which gracefully accommodates two important mechanistic perspectives: the model-adjustment hypothesis [Winkler, I., Karmos, G., Naatanen, R., 1996. Adaptive modelling of tire unattended acoustic environment reflected in the mismatch negativity event-related potential. Brain Res. 742, 239-252; Naatanen, R., Winkler, L, 1999. The concept of auditory stimulus representation in cognitive neuroscience. Psychol Bull 125, 826-859; Sussman, E., Winkler, I., 2001. Dynamic sensory updating in the auditory system. Brain Res. Cogn Brain Res. 12, 431-439] and the adaptation hypothesis [May, P., Tiitinen, H. Ilmoniemi, R.J., Nyman, G., Taylor, J.G., Naatanen,R., 1999. Frequency change detection in human auditory cortex. J. Comput. Neurosci. 6, 99-120; Jaaskelainen, I.P., Ahveninen, J., Bonmassar, G., Dale, A.M., Ilmoniemi, R.J., Levanen, S., Lin, F.H., May, P., Melcher, J., Stufflebeam, S., Tiitinen, H., Belliveau, J.W., 2004. Human posterior auditory cortex gates novel Sounds to consciousness. Proc. Natl. Acad. Sci. U. S. A. 101, 6809-6814]. (C) 2008 Elsevier Inc. All rights reserved.

Type: Article
Title: The functional anatomy of the MMN: A DCM study of the roving paradigm
Open access status: An open access publication
DOI: 10.1016/j.neuroimage.2008.05.018
Publisher version: http://ukpmc.ac.uk/abstract/MED/18602841
Keywords: EVENT-RELATED POTENTIALS, MISMATCH NEGATIVITY, EVOKED-RESPONSES, AUDITORY-CORTEX, TRACE FORMATION, MEMORY, BRAIN, SOUNDS, ERP, CONNECTIONS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/136462
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item