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Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease

Goris, A; Williams-Gray, CH; Foltynie, T; Brown, J; Maranian, M; Walton, A; Compston, DAS; ... Sawcer, SJ; + view all (2007) Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease. J NEUROL , 254 (7) 846 - 848. 10.1007/s00415-006-0414-6.

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Abstract

Given the known roles of TGF beta 2 in both regulating the immune system and promoting the survival of dopaminergic neurons, it is feasible that genetic variations in TGF beta 2 might play an aetiological role in neurological diseases such as Multiple Sclerosis (MS) and Parkinson's disease (PD). Hence we performed an indirect association analysis of TGFB2 using 8 haplotype-tagging SNPs in a population of 937 MS patients, 538 PD cases and 2022 controls. We found no evidence for association with susceptibility or progression of MS, but have demonstrated a trend towards association of the 5' region of the gene with susceptibility to PD. Further analysis of TGFB2 is warranted in other PD cohorts.

Type: Article
Title: Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease
DOI: 10.1007/s00415-006-0414-6
Keywords: Tgf beta 2, genetics, MS, Parkinson's disease, GROWTH-FACTOR-BETA, DISEQUILIBRIUM, POLYMORPHISMS, ASSOCIATION, SURVIVAL, LINKAGE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/136406
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