Khalil, A;
Muttukrishna, S;
Harrington, K;
Jauniaux, E;
(2008)
Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders.
PLOS One
, 3
(7)
, Article e2766. 10.1371/journal.pone.0002766.
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Abstract
Antihypertensive drugs are believed to lower blood pressure in pre-eclampsia by direct or central vasodilatory mechanisms. However, they could also act by decreasing production of anti-angiogenic proteins involved in the pathophysiology of hypertension and proteinuria in pre-eclampsia (PE). The aim of our study was to evaluate the impact of antihypertensive therapy with alpha methyldopa on maternal circulating levels and placental production of soluble fms-like tyrosine kinase 1 (sFlt-1), soluble endoglin (sEng), vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in hypertensive disorders of pregnancy.
| Type: | Article |
|---|---|
| Title: | Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0002766 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0002766 |
| Language: | English |
| Additional information: | © 2008 Khalil et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The authors have no support or funding to report. |
| Keywords: | Angiogenesis Inhibitors, Antigens, CD, Antihypertensive Agents, Female, Humans, Hypertension, Methyldopa, Neovascularization, Pathologic, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnancy Proteins, Receptors, Cell Surface, Ultrasonography, Doppler, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-1 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1362812 |
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