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Genetic determination of plasma lipids and insulin in the Czech population

Hubacek, JA; Waterworth, DM; Poledne, R; Pitha, J; Skodova, Z; Humphries, SE; Talmud, PJ; (2001) Genetic determination of plasma lipids and insulin in the Czech population. CLIN BIOCHEM , 34 (2) 113 - 118.

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Abstract

Objectives: To evaluate the association between plasma lipids and insulin and variation in the genes for apolipoproteins (APO) E (CfoI), B (insertion/deletion). C1 (HpaI), and C3 (C-382T, C3238G) in a population-based Czech Slavonic study.Design and methods: In 131 men and 154 women, polymorphisms were investigated using PCR. In the same subjects plasma lipid levels and insulin were measured.Results: In the women, carriers of the e4 allele had higher apoB (p = 0.03) and triglyceride (p = 0.03) compared to e3 homozygotes, whereas in the men, the effect of the e4 allele was seen on total cholesterol (p = 0.02). LDL cholesterol (p = 0.003) and apoB (p = 0.001). Compared with SP27 (insertion) homozygotes of the APOB polymorphism, women SP24 (deletion) homozygotes had higher levels of total (p = 0.003) and LDL cholesterol (p = 0.007) and apoB (p = 0.05). No significant effect was seen in the men. Women homozygous for the APOC3 -482T allele had higher insulin levels than -482C homozygotes (p = 0.03). Men homozygous for APOC3 -182T allele have the highest plasma triglyceride level (p = 0.02). The APOC1 polymorphism exhibited no significant effect on any of the parameters studied.Conclusions: In this sample, variation at the APOE. APOB and APOC3 genes play a role in determining plasma levels of insulin and lipids, and emphasize the importance of gender-associated effects in the genetic determinations. (C) 2001 The Canadian society of Clinical Chemists. All rights reserved.

Type:Article
Title:Genetic determination of plasma lipids and insulin in the Czech population
Keywords:apolipoprotein E, apolipoprotein B, apolipoprotein C1, apolipoprotein C3, lipids, polymorphism, B SIGNAL PEPTIDE, APOLIPOPROTEIN-C-III, POLYMERASE-CHAIN-REACTION, LOW-DENSITY LIPOPROTEINS, MYOCARDIAL-INFARCTION, APO-B, RESTRICTION SITE, E POLYMORPHISM, ASSOCIATION, METABOLISM
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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