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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.

Costello, DA; Claret, M; Al-Qassab, H; Plattner, F; Irvine, EE; Choudhury, AI; Giese, KP; ... Pedarzani, P; + view all (2012) Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity. PLoS One , 7 (2) , Article e31124. 10.1371/journal.pone.0031124. Green open access

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Abstract

Diabetes mellitus is associated with cognitive deficits and an increased risk of dementia, particularly in the elderly. These deficits and the corresponding neurophysiological structural and functional alterations are linked to both metabolic and vascular changes, related to chronic hyperglycaemia, but probably also defects in insulin action in the brain. To elucidate the specific role of brain insulin signalling in neuronal functions that are relevant for cognitive processes we have investigated the behaviour of neurons and synaptic plasticity in the hippocampus of mice lacking the insulin receptor substrate protein 2 (IRS-2).

Type: Article
Title: Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0031124
Publisher version: http://dx.doi.org/10.1371/journal.pone.0031124
Language: English
Additional information: © 2012 Costello et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3287998
Keywords: Animals, Brain, Diabetes Mellitus, Experimental, Disease Models, Animal, Electrophysiology, Female, Heterozygote, Hippocampus, Hyperglycemia, Insulin Receptor Substrate Proteins, Male, Mice, Mice, Knockout, Neuronal Plasticity, Neurons, Phosphorylation, Receptors, N-Methyl-D-Aspartate, Research Design, Synapses
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1362030
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