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Target-specific expression of presynaptic NMDA receptors in neocortical microcircuits.

Buchanan, KA; Blackman, AV; Moreau, AW; Elgar, D; Costa, RP; Lalanne, T; Tudor Jones, AA; ... Sjöström, PJ; + view all (2012) Target-specific expression of presynaptic NMDA receptors in neocortical microcircuits. Neuron , 75 (3) 451 - 466. 10.1016/j.neuron.2012.06.017. Green open access

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Abstract

Traditionally, NMDA receptors are located postsynaptically; yet, putatively presynaptic NMDA receptors (preNMDARs) have been reported. Although implicated in controlling synaptic plasticity, their function is not well understood and their expression patterns are debated. We demonstrate that, in layer 5 of developing mouse visual cortex, preNMDARs specifically control synaptic transmission at pyramidal cell inputs to other pyramidal cells and to Martinotti cells, while leaving those to basket cells unaffected. We also reveal a type of interneuron that mediates ascending inhibition. In agreement with synapse-specific expression, we find preNMDAR-mediated calcium signals in a subset of pyramidal cell terminals. A tuned network model predicts that preNMDARs specifically reroute information flow in local circuits during high-frequency firing, in particular by impacting frequency-dependent disynaptic inhibition mediated by Martinotti cells, a finding that we experimentally verify. We conclude that postsynaptic cell type determines presynaptic terminal molecular identity and that preNMDARs govern information processing in neocortical columns.

Type: Article
Title: Target-specific expression of presynaptic NMDA receptors in neocortical microcircuits.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2012.06.017
Publisher version: http://dx.doi.org/10.1016/j.neuron.2012.06.017
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3657167
Keywords: Animals, Computer Simulation, Excitatory Postsynaptic Potentials, Mice, Mice, Transgenic, Microscopy, Confocal, Neocortex, Neural Pathways, Neuronal Plasticity, Neurons, Patch-Clamp Techniques, Presynaptic Terminals, Receptors, N-Methyl-D-Aspartate, Synaptic Transmission
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1361689
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