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THE INJURED CELL - THE ROLE OF THE DENDRITIC CELL SYSTEM AS A SENTINEL RECEPTOR PATHWAY

IBRAHIM, MAA; CHAIN, BM; KATZ, DR; (1995) THE INJURED CELL - THE ROLE OF THE DENDRITIC CELL SYSTEM AS A SENTINEL RECEPTOR PATHWAY. IMMUNOL TODAY , 16 (4) 181 - 186.

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Abstract

A major unresolved paradox in immunology remains: how do we avoid harm, despite the abundant opportunities for induction of immune responses against self-proteins? Here, Mohammad Ibrahim, Benjamin Chain and David Katz extend Janeway's proposed explanation arguing that adaptive immune responses are initiated not only by conserved microbial products, but also by microenvironmental tissue injury They suggest that the key step is local dendritic cell activation, followed by upregulation of T-cell costimulatory molecules on these cells, and migration, leading to antigen presentation.

Type: Article
Title: THE INJURED CELL - THE ROLE OF THE DENDRITIC CELL SYSTEM AS A SENTINEL RECEPTOR PATHWAY
Keywords: MAJOR HISTOCOMPATIBILITY COMPLEX, TOXIC LYMPHOCYTE-T, LANGERHANS CELLS, IMMUNE-RESPONSES, GM-CSF, ANTIGEN, MACROPHAGE, RAT, PHAGOCYTOSIS, STIMULATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/136108
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