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Metabolome-Wide Association Study Identifies Multiple Biomarkers that Discriminate North and South Chinese Populations at Differing Risks of Cardiovascular Disease INTERMAP Study

Yap, IKS; Brown, IJ; Chan, Q; Wijeyesekera, A; Garcia-Perez, I; Bictash, M; ... Holmes, E; + view all (2010) Metabolome-Wide Association Study Identifies Multiple Biomarkers that Discriminate North and South Chinese Populations at Differing Risks of Cardiovascular Disease INTERMAP Study. J PROTEOME RES , 9 (12) 6647 - 6654. 10.1021/pr100798r.

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Abstract

Rates of heart disease and stroke vary markedly between north and south China A H-1 NMR spectroscopy-based metabolome-wide association approach was used to identify urinary metabolites that discriminate between southern and northern Chinese population samples, to investigate population biomarkers that might relate to the difference in cardiovascular disease risk NMR spectra were acquired from two 24 h urine specimens per person for 523 northern and 244 southern Chinese participants in the INTERMAP Study of macro/micronutrients and blood pressure Discriminating metabolites were identified using orthogonal partial least squares discriminant analysis and assessed for statistical significance with conservative family wise error rate < 0 01 to minimize false positive findings Urinary metabolites significantly (P < 1 2 x 10(-16) to 2 9 x 10(-69)) higher in northern than southern Chinese populations included dimethylglycine alanine lactate branched chain amino acids (isoleucine leucine valine), N acetyls of glycoprotein fragments (including uromodulin) N acetyl neuraminic acid pentanoic/heptanoic acid, and methylguanidine, metabolites significantly (P < 1 1 X 10(-12) to 2 x 10(-127)) higher in the south were gut microbial cometabolites (hippurate, 4-cresyl sulfate phenylacetylglutamine 2 hydroxyisobutyrate), succinate, creatine, scyllo inositol, prolinebetaine, and trans aconitate These findings indicate the importance of environmental influences (e g, diet), endogenous metabolism, and mammalian-gut microbial cometabolism, which may help explain north-south China differences in cardiovascular disease risk

Type:Article
Title:Metabolome-Wide Association Study Identifies Multiple Biomarkers that Discriminate North and South Chinese Populations at Differing Risks of Cardiovascular Disease INTERMAP Study
DOI:10.1021/pr100798r
Keywords:H-1 NMR, blood pressure, epidemiology, gut microbial cometabolites, INTERMAP, metabolome wide association, metabonomics, nutrition, BLOOD-PRESSURE, GUT MICROBIOTA, HAN CHINESE, EXCRETION, SPECTROSCOPY, OBESITY, EPIDEMIOLOGY, PHENOTYPES, DILUTION, DIET
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Statistical Science

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